Abstract
In pathogenesis of the traumatic disease of the spinal cord, two mechanisms of the injuries of its neuronal apparatus are defined: primary (necrosis) and secondary (apoptosis). In the work a participation of a number of internal causes in the progression of apoptosis in injury of the spinal cord and peripheral nerve trunks, the role of those remains little-studied up to date, is discussed.
MeSH terms
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Animals
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Apoptosis / genetics*
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Caspases / genetics
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Caspases / metabolism
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Cytokines / genetics
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Cytokines / metabolism
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Gene Expression Regulation
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Humans
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Necrosis / genetics
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Necrosis / metabolism
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Necrosis / physiopathology*
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Peripheral Nerve Injuries / genetics
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Peripheral Nerve Injuries / metabolism
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Peripheral Nerve Injuries / physiopathology*
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Peripheral Nerves / metabolism
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Peripheral Nerves / physiopathology*
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Reactive Oxygen Species / metabolism
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Signal Transduction
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Spinal Cord / metabolism
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Spinal Cord / physiopathology*
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Spinal Cord Injuries / genetics
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Spinal Cord Injuries / metabolism
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Spinal Cord Injuries / physiopathology*
Substances
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Cytokines
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Proto-Oncogene Proteins c-bcl-2
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Reactive Oxygen Species
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Caspases