The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells

Niels Weinhold; Tobias Meissner; David C Johnson; Anja Seckinger; Jérôme Moreaux; Asta Försti; Bowang Chen; Jolanta Nickel; Daniel Chubb; Andrew C Rawstron; Chi Doughty; Nasrin B Dahir; Dil B Begum; Kwee Young; Brian A Walker; Per Hoffmann; Marcus M Nöthen; Faith E Davies; Bernard Klein; Hartmut Goldschmidt; Gareth J Morgan; Richard S Houlston; Dirk Hose; Kari Hemminki

doi:10.3324/haematol.2014.118786

The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells

Haematologica. 2015 Mar;100(3):e110-3. doi: 10.3324/haematol.2014.118786. Epub 2014 Dec 5.

Authors

Niels Weinhold¹, Tobias Meissner², David C Johnson³, Anja Seckinger¹, Jérôme Moreaux⁴, Asta Försti⁵, Bowang Chen⁶, Jolanta Nickel¹, Daniel Chubb⁷, Andrew C Rawstron⁸, Chi Doughty⁸, Nasrin B Dahir³, Dil B Begum³, Kwee Young⁹, Brian A Walker³, Per Hoffmann¹⁰, Marcus M Nöthen¹¹, Faith E Davies³, Bernard Klein⁴, Hartmut Goldschmidt¹², Gareth J Morgan³, Richard S Houlston⁷, Dirk Hose¹³, Kari Hemminki⁵

Affiliations

¹ Department of Internal Medicine V, University of Heidelberg, Germany.
² Department of Internal Medicine V, University of Heidelberg, Germany Department of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
³ Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
⁴ INSERM, Unité 1040, Institut de Recherche en Biothérapie, Centre Hospitalier Universitaire de Montpellier, Hôpital Saint Eloi, Avenue Augustin Fliche, 34295 Montpellier, France.
⁵ German Cancer Research Center, Heidelberg, Germany Center for Primary Health Care Research, Lund University, Malmo, Sweden.
⁶ German Cancer Research Center, Heidelberg, Germany.
⁷ Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
⁸ Haematological Malignancy Diagnostic Service Laboratory, St James University Hospital, Leeds, UK.
⁹ Department of Haematology, University College London Hospital, UK.
¹⁰ Institute of Human Genetics, University of Bonn, Germany Division of Medical Genetics, Department of Biomedicine, University of Basel, Switzerland.
¹¹ Institute of Human Genetics, University of Bonn, Germany Department of Genomics, Life & Brain Center, University of Bonn, Germany.
¹² Department of Internal Medicine V, University of Heidelberg, Germany National Centre for Tumor Diseases, Heidelberg, Germany.
¹³ Department of Internal Medicine V, University of Heidelberg, Germany National Centre for Tumor Diseases, Heidelberg, Germany dirk.hose@med.uni-heidelberg.de.

No abstract available

Keywords: eQTL; multiple myeloma; risk; single nucleotide polymorphism.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alleles
Binding Sites
Chromosome Mapping
Chromosomes, Human, Pair 7*
Female
Gene Expression Regulation, Neoplastic*
Humans
Interferon Regulatory Factors / genetics*
Interferon Regulatory Factors / metabolism
Male
Middle Aged
Multiple Myeloma / genetics*
Multiple Myeloma / metabolism
Multiple Myeloma / pathology
Plasma Cells / metabolism
Plasma Cells / pathology
Polymorphism, Single Nucleotide
Protein Binding
Proto-Oncogene Proteins c-myc / genetics*
Proto-Oncogene Proteins c-myc / metabolism
Quantitative Trait Loci
Repressor Proteins / genetics*
Repressor Proteins / metabolism
Signal Transduction

Substances

CDCA7L protein, human
Interferon Regulatory Factors
MYC protein, human
Proto-Oncogene Proteins c-myc
Repressor Proteins
interferon regulatory factor-4