Acute myocardial infarction in a young woman on isotretinoin treatment

Int J Cardiol. 2015 Feb 15:181:39-41. doi: 10.1016/j.ijcard.2014.11.169. Epub 2014 Nov 25.

Abstract

The use of isotretinoin has been associated with mild changes in the metabolic profile of adolescents. In very rare cases, a possible association with myocardial infarction, stroke and thromboembolic events has been reported. In this report we describe the potential association of isotretinoin with the occurrence of an acute myocardial infarction in a very young girl. OCT provided unique visualization of the culprit lesion.

Keywords: Isotretinoin; Myocardial infarction; Optical coherence tomography.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Acne Vulgaris / drug therapy
  • Adult
  • Coronary Angiography / methods
  • Coronary Vessels / diagnostic imaging
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / adverse effects
  • Female
  • Humans
  • Isotretinoin* / administration & dosage
  • Isotretinoin* / adverse effects
  • Myocardial Infarction* / diagnosis
  • Myocardial Infarction* / etiology
  • Myocardial Infarction* / physiopathology
  • Myocardial Infarction* / surgery
  • Thrombectomy / methods*
  • Tomography, Optical Coherence / methods
  • Treatment Outcome

Substances

  • Dermatologic Agents
  • Isotretinoin