Acetate fuels the cancer engine

Cell. 2014 Dec 18;159(7):1492-4. doi: 10.1016/j.cell.2014.12.009.

Abstract

Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and histone modification.

Publication types

  • Research Support, Non-U.S. Gov't