[Bronchial thermoplasty in the treatment of severe adult asthma]

Abstract

Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based treatment, the evaluation procedure of risks and benefits is different that for pharmaceutical products; safety aspects, regulatory requirements, study design and the assessment of the magnitude of effects may all be different. The mechanism of action and optimal patient selection need to be assessed further in rigorous clinical and scientific studies. This technique is in harmony with the development of personalised medicine in the 21st century. It should be developed further in response to the numerous challenges and needs not yet met in the management of severe asthma.

Keywords: Asthma exacerbation; Asthma phenotypes; Asthme sévère; Bronchial endoscopy; Bronchial thermoplasty; Endoscopie bronchique; Exacerbation; Phénotypes de l’asthme; Severe asthma; Thermoplastie bronchique.