Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-β

Philip L S M Gordts; Jeffrey D Esko

doi:10.1016/j.cyto.2014.12.013

Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-β

Cytokine. 2015 Mar;72(1):118-9. doi: 10.1016/j.cyto.2014.12.013. Epub 2015 Jan 5.

Authors

Philip L S M Gordts¹, Jeffrey D Esko²

Affiliations

¹ Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
² Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address: jesko@ucsd.edu.

PMID: 25573804
DOI: 10.1016/j.cyto.2014.12.013

Abstract

Macrophages are important mediators of diseases associated with metabolic inflammation such as obesity and atherosclerosis. In this Stimulus we discuss recent findings showing that heparan sulfate proteoglycans on macrophages serve as an important inflammatory rheostat. This observation has significant implications as the degree of macrophage proteoglycan sulfation can determine and possibly predict disease outcomes of metabolic inflammatory disorders.

Keywords: Atherosclerosis; Heparan sulfate proteoglycans; Macrophages; Obesity; Type I Interferon.

MeSH terms

Animals
Cells, Cultured
Heparan Sulfate Proteoglycans / immunology*
Humans
Inflammation* / metabolism
Interferon-beta / genetics
Interferon-beta / metabolism*
Macrophages / immunology*
Macrophages / physiology
Mice

Substances

Heparan Sulfate Proteoglycans
Interferon-beta