Abstract
Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 μM.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinomycetales / chemistry*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Biological Products / chemistry
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Biological Products / isolation & purification*
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Thiazines / chemistry
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Thiazines / isolation & purification*
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Thiazines / pharmacology
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Thiazoles / chemistry
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Thiazoles / isolation & purification*
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Thiazoles / pharmacology
Substances
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Antineoplastic Agents
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Biological Products
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Thiazines
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Thiazoles
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thiasporine A
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thiasporine B
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thiasporine C