Apparent non-involvement of prions in the pathogenesis of spongiform change in HIV-infected brain

P N Goldwater; J C Paton

doi:10.1097/00005072-198903000-00005

Apparent non-involvement of prions in the pathogenesis of spongiform change in HIV-infected brain

J Neuropathol Exp Neurol. 1989 Mar;48(2):184-6. doi: 10.1097/00005072-198903000-00005.

Authors

P N Goldwater¹, J C Paton

Affiliation

¹ Department of Microbiology, Adelaide Children's Hospital, South Australia.

PMID: 2564045
DOI: 10.1097/00005072-198903000-00005

Abstract

Characteristic neuropathological white matter changes in the brains of patients dying from the acquired immune deficiency syndrome (AIDS) suggest pathogenetic involvement of either the PrP27-30 gene or a scrapie-related prion; however, proteinase-K resistant scrapie-like proteins could not be detected in brain tissue from AIDS patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acquired Immunodeficiency Syndrome / metabolism*
Blotting, Western
Brain Chemistry*
Humans
PrP 27-30 Protein
Prions*
Viral Proteins / analysis

Substances

Prions
Viral Proteins
PrP 27-30 Protein