Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia

Gang Chen; Qiang Fu; Jiangbei Cao; Weidong Mi

doi:10.3969/j.issn.1673-5374.2012.21.007

Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia

Neural Regen Res. 2012 Jul 25;7(21):1645-9. doi: 10.3969/j.issn.1673-5374.2012.21.007.

Authors

Gang Chen¹, Qiang Fu¹, Jiangbei Cao¹, Weidong Mi¹

Affiliation

¹ Anesthesia and Operation Center, PLA General Hospital, Beijing 100853, China.

PMID: 25657705
PMCID: PMC4308767
DOI: 10.3969/j.issn.1673-5374.2012.21.007

Abstract

We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia. A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, and cAMP in the hippocampus of aged rats with chronic cerebral ischemia, but a high-dose of propofol inhibited their expression. Results indicated that the protective effect of propofol against cerebral ischemia in aged rats is related to changes in the expression of brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus, and that the cAMP-cAMP responsive element binding protein pathway is involved in the regulatory effect of propofol on brain-derived neurotrophic factor expression.

Keywords: aged; brain-derived neurotrophic factor; cAMP-cAMP responsive element binding protein; chronic cerebral ischemia; neural regeneration; propofol; tyrosine kinase receptor B.