SIRT1 synchs satellite cell metabolism with stem cell fate

Cell Stem Cell. 2015 Feb 5;16(2):103-4. doi: 10.1016/j.stem.2015.01.006.

Abstract

Metabolic reprogramming of muscle stem cells modulates myogenic cell fate. In this issue of Cell Stem Cell, Ryall et al. (2015) show that SIRT1, a NAD(+)-dependent histone deacetylase, acts as an epigenetic regulator that connects changes in satellite cell metabolism with changes in the transcriptional machinery toward myogenic commitment.

Publication types

  • Research Support, N.I.H., Intramural
  • Comment

MeSH terms

  • Animals
  • Epigenesis, Genetic*
  • Muscle, Skeletal / cytology*
  • Muscle, Skeletal / metabolism*
  • NAD / metabolism*
  • Sirtuin 1 / metabolism*
  • Stem Cells / cytology*
  • Stem Cells / metabolism*

Substances

  • NAD
  • Sirtuin 1