Can the irradiated brain be salvaged by oligodendrocyte precursor transplantation?

Marie C Harrisingh; Charles ffrench-Constant

doi:10.1016/j.stem.2015.01.010

Can the irradiated brain be salvaged by oligodendrocyte precursor transplantation?

Cell Stem Cell. 2015 Feb 5;16(2):113-4. doi: 10.1016/j.stem.2015.01.010.

Authors

Marie C Harrisingh¹, Charles ffrench-Constant²

Affiliations

¹ MRC Centre for Regenerative Medicine, University of Edinburgh, SCRM Building, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
² MRC Centre for Regenerative Medicine, University of Edinburgh, SCRM Building, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK. Electronic address: cffc@ed.ac.uk.

PMID: 25658367
DOI: 10.1016/j.stem.2015.01.010

Abstract

Radiotherapy is a mainstay of brain cancer treatment, but it causes significant complications. In this issue of Cell Stem Cell, Piao et al. (2015) derive oligodendrocyte precursors from human embryonic stem cells and show that engrafted cells replenish depleted precursor numbers, generate new myelin, and reverse behavioral defects in irradiated rats.

Publication types

Comment

MeSH terms

Animals
Brain / cytology*
Brain / radiation effects*
Cognition Disorders / etiology*
Cognition Disorders / therapy*
Female
Human Embryonic Stem Cells / cytology*
Humans
Myelin Sheath / metabolism*
Oligodendroglia / cytology*