Dysosesquiflorins A and B, sesquiterpenoids from Dysoxylum densiflorum

Alfarius E Nugroho; Rio Sugiura; Takanori Momota; Yusuke Hirasawa; Chin Piow Wong; Toshio Kaneda; A Hamid A Hadi; Hiroshi Morita

doi:10.1007/s11418-015-0888-6

Dysosesquiflorins A and B, sesquiterpenoids from Dysoxylum densiflorum

J Nat Med. 2015 Jul;69(3):411-5. doi: 10.1007/s11418-015-0888-6. Epub 2015 Feb 7.

Authors

Alfarius E Nugroho¹, Rio Sugiura, Takanori Momota, Yusuke Hirasawa, Chin Piow Wong, Toshio Kaneda, A Hamid A Hadi, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-Ku, Tokyo, 142-8501, Japan.

PMID: 25663447
DOI: 10.1007/s11418-015-0888-6

Abstract

Two new aromadendrane sesquiterpenoids, dysosesquiflorins A and B (1 and 2), were isolated from Dysoxylum densiflorum bark, and their structures were elucidated on the basis of NMR spectroscopic data. These dysosesquiflorins showed in vitro cytotoxic activity against several cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Inhibitory Concentration 50
MCF-7 Cells
Meliaceae / chemistry*
Molecular Structure
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Sesquiterpenes
dysosesquiflorin A
dysosesquiflorin B