Nuclease resistant oligonucleotides with cell penetrating properties

Stefan Milton; Dmytro Honcharenko; Cristina S J Rocha; Pedro M D Moreno; C I Edvard Smith; Roger Strömberg

doi:10.1039/c4cc08837a

Nuclease resistant oligonucleotides with cell penetrating properties

Chem Commun (Camb). 2015 Mar 7;51(19):4044-7. doi: 10.1039/c4cc08837a.

Authors

Stefan Milton¹, Dmytro Honcharenko, Cristina S J Rocha, Pedro M D Moreno, C I Edvard Smith, Roger Strömberg

Affiliation

¹ Karolinska Institutet, Department of Biosciences and Nutrition, Novum, Hälsovägen 7, SE-14183, Huddinge, Sweden. Roger.Stromberg@ki.se.

PMID: 25664358
DOI: 10.1039/c4cc08837a

Abstract

2'-O-AECM modified oligonucleotides provide an unusual combination of remarkable properties. This includes the combination of high resistance towards enzymatic degradation and the spontaneous cellular uptake of AECM oligonucleotides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Transport
Cell Line, Tumor
Esterases / metabolism*
Humans
Oligonucleotides / chemistry*
Oligonucleotides / metabolism*

Substances

Oligonucleotides
Esterases