Abstract
Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days. This rebound effect may be related to dopaminergic receptor changes in the tuberoinfundibular system that are induced by chronic neuroleptic administration.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antipsychotic Agents / adverse effects*
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Antipsychotic Agents / therapeutic use
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Brain / drug effects
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Female
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Fluphenazine / adverse effects
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Haloperidol / adverse effects
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Humans
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Male
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Prolactin / blood*
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Psychotic Disorders / blood
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Psychotic Disorders / drug therapy*
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Receptors, Dopamine / drug effects*
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Schizophrenia / blood
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Schizophrenia / drug therapy*
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Substance Withdrawal Syndrome / blood*
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Trifluoperazine / adverse effects
Substances
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Antipsychotic Agents
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Receptors, Dopamine
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Trifluoperazine
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Prolactin
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Haloperidol
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Fluphenazine