Ponatinib is not transported by ABCB1, ABCG2 or OCT-1 in CML cells

Leukemia. 2015 Aug;29(8):1792-4. doi: 10.1038/leu.2015.35. Epub 2015 Feb 13.
No abstract available

Publication types

  • Letter

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / metabolism
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters / metabolism*
  • Antineoplastic Agents / pharmacokinetics*
  • Humans
  • Imidazoles / pharmacokinetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism*
  • Neoplasm Proteins / metabolism*
  • Organic Cation Transporter 1 / metabolism*
  • Pyridazines / pharmacokinetics*
  • Tissue Distribution
  • Tumor Cells, Cultured

Substances

  • ABCB1 protein, human
  • ABCG2 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters
  • Antineoplastic Agents
  • Imidazoles
  • Neoplasm Proteins
  • Organic Cation Transporter 1
  • Pyridazines
  • ponatinib