Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection

A Webster; C A Lee; D G Cook; J E Grundy; V C Emery; P B Kernoff; P D Griffiths

doi:10.1016/s0140-6736(89)90312-7

Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection

Lancet. 1989 Jul 8;2(8654):63-6. doi: 10.1016/s0140-6736(89)90312-7.

Authors

A Webster¹, C A Lee, D G Cook, J E Grundy, V C Emery, P B Kernoff, P D Griffiths

Affiliation

¹ Department of Virology, Royal Free Hospital, School of Medicine, London.

PMID: 2567870
DOI: 10.1016/s0140-6736(89)90312-7

Abstract

To examine whether cytomegalovirus (CMV) infection could accelerate progression of human immunodeficiency virus (HIV) infection to AIDS, serological studies were done on 108 HIV-infected haemophiliacs. In the 1.3-9 years from time of first recognised HIV seroconversion, the age-adjusted risk of CDC group IV disease in CMV-seropositive patients was 2.5 times that in CMV-seronegative patients. CMV-seropositive patients were also more likely to have detectable p24 antigenaemia. Survival analysis showed that CMV-seropositive patients were at greater risk of HIV disease than CMV-seronegative patients from about 2 years after HIV seroconversion. Thus CMV infection is associated with a more rapid progression to HIV disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acquired Immunodeficiency Syndrome / microbiology*
Adolescent
Adult
Child
Cytomegalovirus Infections / complications*
HIV Seropositivity / complications*
Hemophilia A / complications*
Humans
Virus Activation