Target-specific 3D DNA gatekeepers for biomimetic nanopores

Wei Guo; Fan Hong; Nannan Liu; Jiayu Huang; Boya Wang; Ruixue Duan; Xiaoding Lou; Fan Xia

doi:10.1002/adma.201405078

Target-specific 3D DNA gatekeepers for biomimetic nanopores

Adv Mater. 2015 Mar 25;27(12):2090-5. doi: 10.1002/adma.201405078. Epub 2015 Feb 12.

Authors

Wei Guo¹, Fan Hong, Nannan Liu, Jiayu Huang, Boya Wang, Ruixue Duan, Xiaoding Lou, Fan Xia

Affiliation

¹ Key Laboratory for Large-Format Battery Materials and Systems, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P.R. China; Laboratory of Bio-Inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.

PMID: 25683922
DOI: 10.1002/adma.201405078

Abstract

3D cross-linked DNA superstructures switch off the ionic flux through solid-state nanopores with extremely high ON-OFF ratios of 10(3) -10(5) . This gating mechanism can be generally applicable in a wide range of nanopores with opening diameters up to 650 nm. The 3D bio-supramolecular gatekeepers outperform previous low-dimensional or simple-structured DNA functional components.

Keywords: DNA; biomimetics; gating; nanopores; responsive materials; smart materials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomimetic Materials / chemistry*
DNA / chemistry*
Models, Molecular
Nanopores*
Nucleic Acid Conformation
Nucleic Acid Hybridization

Substances

DNA