Abstract
UK 69 578 is a competitive inhibitor of endopeptidase 24.11 (the enzyme that degrades atrial natriuretic factor) in vitro. In vivo, UK 69 578 has renal and cardiovascular effects similar to low-dose atrial natriuretic factor infusion, and may be a useful agent in hypertension and heart failure.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Animals
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Atrial Natriuretic Factor / antagonists & inhibitors*
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Atrial Natriuretic Factor / blood
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Clinical Trials as Topic
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Coronary Disease / blood
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Coronary Disease / drug therapy
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Cyclohexanecarboxylic Acids*
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Dogs
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Dose-Response Relationship, Drug
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Double-Blind Method
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Drug Evaluation
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Drug Evaluation, Preclinical
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Half-Life
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Humans
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Infusions, Intravenous
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Male
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Middle Aged
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Natriuresis / drug effects
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Nephrectomy
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Neprilysin / antagonists & inhibitors*
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Neprilysin / blood
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Neprilysin / pharmacology
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Rats
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Rats, Inbred Strains
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Time Factors
Substances
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Cyclohexanecarboxylic Acids
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candoxatrilat
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Atrial Natriuretic Factor
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Neprilysin