A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis

Tissue Antigens. 2015 Mar;85(3):204-8. doi: 10.1111/tan.12535.

Abstract

Toll-like receptor 3 (TLR3) may be associated with T helper 1 immune response. This study aimed to investigate the role of a functional TLR3 single nucleotide polymorphism (SNP) in sarcoidosis. We genotyped 220 Japanese patients with sarcoidosis and 140 controls for TLR3 SNP rs3775291 to analyze its association with susceptibility to sarcoidosis and assessed its relationship to clinical features in 172 patients over 2 years. The TLR3 rs3775291 genotype was not significantly associated with disease susceptibility. However, patients with cardiac sarcoidosis (CS) significantly more frequently had the TT genotype (p < 0.01) or the T allele (p < 0.05) than those patients without CS. We conclude that TLR3 SNP rs3775291 may affect cardiac involvement in Japanese patients with sarcoidosis.

Keywords: cardiac sarcoidosis; single nucleotide polymorphism; toll-like receptor 3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Female
  • Gene Expression
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Myocardium / immunology
  • Myocardium / pathology
  • Polymorphism, Single Nucleotide*
  • Sarcoidosis / genetics*
  • Sarcoidosis / immunology
  • Sarcoidosis / pathology
  • Toll-Like Receptor 3 / genetics*
  • Toll-Like Receptor 3 / immunology

Substances

  • TLR3 protein, human
  • Toll-Like Receptor 3