Integrating p38α MAPK immune signals in nonimmune cells

Sci Signal. 2015 Mar 3;8(366):fs5. doi: 10.1126/scisignal.aaa8398.

Abstract

A study by Huang et al. in this issue of Science Signaling highlights key roles for the mitogen-activated protein kinase p38α and the phosphatase MK1 in mediating interleukin-17-dependent pathology in experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Dual Specificity Phosphatase 1 / immunology*
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Humans
  • MAP Kinase Signaling System / immunology*
  • Mitogen-Activated Protein Kinase 14 / immunology*
  • Multiple Sclerosis / immunology*
  • Receptors, Interleukin-17 / immunology*

Substances

  • Receptors, Interleukin-17
  • Mitogen-Activated Protein Kinase 14
  • Dual Specificity Phosphatase 1