VHL: Cullin-g the hypoxic response

Nadia J Kershaw; Jeffrey J Babon

doi:10.1016/j.str.2015.02.003

VHL: Cullin-g the hypoxic response

Structure. 2015 Mar 3;23(3):435-436. doi: 10.1016/j.str.2015.02.003.

Authors

Nadia J Kershaw¹, Jeffrey J Babon²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia.
² The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: babon@wehi.edu.au.

PMID: 25738382
DOI: 10.1016/j.str.2015.02.003

Abstract

Hypoxia inducible factor (HIF)-mediated response to hypoxic conditions is turned off by VHL-mediated ubiquitination of HIFα. To achieve this, VHL binds HIFα and recruits it to a specific E3 ubiquitin ligase complex, a Cullin-RING-ligase. In this issue of Structure, Nguyen et al. provide a structural view of how VHL engages the ligase in order to inhibit the hypoxic response.

Publication types

Comment

MeSH terms

Humans
Transcription Factors / chemistry*
Von Hippel-Lindau Tumor Suppressor Protein / chemistry*

Substances

Transcription Factors
Von Hippel-Lindau Tumor Suppressor Protein