Autosomal dominant polycystic kidney disease: prenatal diagnosis by DNA analysis and sonography at 14 weeks

Prenat Diagn. 1989 Nov;9(11):751-8. doi: 10.1002/pd.1970091103.

Abstract

A pregnant woman affected with autosomal dominant polycystic kidney disease (ADPKD) had a history of an affected fetus, diagnosed by sonography at 29 weeks of pregnancy. The proband's father was also affected. DNA analysis performed on chorionic villi at 11 weeks during a second pregnancy predicted an affected fetus, and sonographic examination at 14 weeks confirmed the diagnosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Fetal Diseases / diagnosis*
  • Humans
  • Kidney / pathology
  • Male
  • Pedigree
  • Polycystic Kidney Diseases / diagnosis*
  • Polycystic Kidney Diseases / genetics
  • Polymorphism, Restriction Fragment Length*
  • Pregnancy
  • Prenatal Diagnosis*
  • Ultrasonography*