Structure and Dynamics of the Native HIV-1 Env Trimer

J Virol. 2015 Jun;89(11):5752-5. doi: 10.1128/JVI.03187-14. Epub 2015 Mar 11.

Abstract

HIV-1/AIDS remains one of the worst pandemics in human history. Despite tremendous efforts, no effective vaccine has been found. Recent reports give new insights into the structure and dynamics of the HIV-1 Env trimer and renew hopes that a better understanding of Env will translate into new vaccine candidates and more-effective antiretroviral therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • AIDS Vaccines / immunology
  • AIDS Vaccines / isolation & purification
  • HIV Envelope Protein gp120 / chemistry*
  • HIV Envelope Protein gp120 / immunology
  • HIV Envelope Protein gp120 / metabolism
  • HIV Envelope Protein gp41 / chemistry*
  • HIV Envelope Protein gp41 / immunology
  • HIV Envelope Protein gp41 / metabolism
  • HIV-1 / chemistry*
  • HIV-1 / immunology
  • Humans
  • Models, Molecular
  • Protein Conformation
  • Protein Multimerization*

Substances

  • AIDS Vaccines
  • HIV Envelope Protein gp120
  • HIV Envelope Protein gp41
  • gp120 protein, Human immunodeficiency virus 1
  • gp41 protein, Human immunodeficiency virus 1