Antibody conjugates bispecific for intercellular adhesion molecule 1 and allergen prevent migration of allergens through respiratory epithelial cell layers

J Allergy Clin Immunol. 2015 Aug;136(2):490-3.e11. doi: 10.1016/j.jaci.2015.01.006. Epub 2015 Mar 11.

Authors

Christoph Madritsch¹, Julia Eckl-Dorna², Katharina Blatt³, Isabella Ellinger⁴, Michael Kundi⁵, Verena Niederberger², Peter Valent³, Rudolf Valenta¹, Sabine Flicker⁶

Affiliations

¹ Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
² Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
³ Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
⁴ Division of Cellular and Molecular Pathophysiology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
⁵ Institute of Environmental Health, Center of Public Health, Medical University of Vienna, Vienna, Austria.
⁶ Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: sabine.flicker@meduniwien.ac.at.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Allergens / chemistry
Allergens / immunology*
Antibodies, Bispecific / biosynthesis*
Antibodies, Bispecific / chemistry
Basophils / drug effects
Basophils / immunology
Basophils / pathology
Biotin / chemistry
Bronchi / drug effects
Bronchi / immunology
Bronchi / pathology
Cell Line
Epithelial Cells / drug effects
Epithelial Cells / immunology
Epithelial Cells / pathology
Humans
Hypersensitivity / drug therapy*
Hypersensitivity / immunology
Hypersensitivity / pathology
Immunoconjugates / chemistry
Immunoconjugates / pharmacology*
Intercellular Adhesion Molecule-1 / chemistry
Intercellular Adhesion Molecule-1 / immunology*
Microscopy, Fluorescence
Plant Proteins / antagonists & inhibitors*
Plant Proteins / immunology
Primary Cell Culture
Protein Transport / drug effects
Respiratory Mucosa / drug effects
Respiratory Mucosa / immunology
Respiratory Mucosa / pathology
Streptavidin / chemistry

Substances

Allergens
Antibodies, Bispecific
ICAM1 protein, human
Immunoconjugates
PHLPII protein, Phleum pratense
Plant Proteins
Intercellular Adhesion Molecule-1
Biotin
Streptavidin

Grants and funding