Role of NF-κB/IKK-dependent signaling in functional stimulation of mesenchymal progenitor cells by alkaloid songorine

Bull Exp Biol Med. 2015 Mar;158(5):624-7. doi: 10.1007/s10517-015-2822-z. Epub 2015 Mar 17.

Abstract

We studied the role of NF-κB/IKK-mediated signaling in the stimulation of growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Specific NF-κB inhibitor oridonin abolished activation of proliferation and differentiation of progenitor cells. Aurothiomalate, a selective blocker of IKK-2, also suppressed mitotic activity of fibroblast precursors, but had no effect on the rate of the differentiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / pharmacology*
  • Animals
  • Cell Differentiation / drug effects
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Diterpenes, Kaurane / pharmacology
  • Gold Sodium Thiomalate / pharmacology
  • I-kappa B Kinase / antagonists & inhibitors
  • I-kappa B Kinase / metabolism*
  • Mesenchymal Stem Cells / drug effects*
  • Mesenchymal Stem Cells / metabolism*
  • Mice
  • Models, Biological
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism*
  • Regenerative Medicine

Substances

  • Alkaloids
  • Diterpenes, Kaurane
  • NF-kappa B
  • oridonin
  • Gold Sodium Thiomalate
  • songorine
  • I-kappa B Kinase
  • Ikbkb protein, mouse