Biotechnology. A prudent path forward for genomic engineering and germline gene modification

David Baltimore; Paul Berg; Michael Botchan; Dana Carroll; R Alta Charo; George Church; Jacob E Corn; George Q Daley; Jennifer A Doudna; Marsha Fenner; Henry T Greely; Martin Jinek; G Steven Martin; Edward Penhoet; Jennifer Puck; Samuel H Sternberg; Jonathan S Weissman; Keith R Yamamoto

doi:10.1126/science.aab1028

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19.

Authors

David Baltimore¹, Paul Berg², Michael Botchan³, Dana Carroll⁴, R Alta Charo⁵, George Church⁶, Jacob E Corn⁷, George Q Daley⁸, Jennifer A Doudna⁹, Marsha Fenner⁷, Henry T Greely¹⁰, Martin Jinek¹¹, G Steven Martin¹², Edward Penhoet¹³, Jennifer Puck¹⁴, Samuel H Sternberg¹⁵, Jonathan S Weissman¹⁶, Keith R Yamamoto¹⁷

Affiliations

¹ California Institute of Technology, Mail Code 147-75, Pasadena, CA 91125, USA.
² Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305, USA.
³ University of California, Berkeley, 450 Li Ka Shing no. 3370, Berkeley, CA 94720-3370, USA. Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA.
⁴ Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Room 4100, Salt Lake City, UT 84112-5650, USA.
⁵ Department of Medical History and Bioethics, School of Medicine and Public Health, University of Wisconsin Law School, 975 Bascom Mall, Madison, WI 53706, USA.
⁶ Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
⁷ Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA.
⁸ Boston Children's Hospital, 300 Longwood Avenue, Karp Family Building, 7th Floor, Boston, MA 02115, USA. Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA.
⁹ Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA. Departments of Molecular and Cell Biology and Chemistry, Howard Hughes Medical Institute, 731 Stanley Hall, MS 3220, University of California, Berkeley, Berkeley, CA 94720-3220, USA. doudna@berkeley.edu.
¹⁰ Center for Law and the Biosciences, Crown Quadrangle 559 Nathan Abbott Way Stanford, CA 94305-8610, USA.
¹¹ Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
¹² Department of Molecular and Cell Biology, College of Letters and Science, University of California, Berkeley, 210K Durant Hall, Berkeley, CA 94720-2920, USA.
¹³ Alta Partners, One Embarcadero Center, 37th Floor, San Francisco, CA 94111, USA.
¹⁴ Department of Pediatrics UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
¹⁵ Department of Chemistry, 731 Stanley Hall, MS 3220, University of California, Berkeley, CA 94720-3220, USA.
¹⁶ Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA. Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, Byers Hall, 1700 4th Street, San Francisco, CA 94158-2330, USA.
¹⁷ Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA. UCSF School of Medicine, 600 16th Street, San Francisco, CA 94158, USA.

Abstract

A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biotechnology / ethics
Clustered Regularly Interspaced Short Palindromic Repeats*
Gene Transfer, Horizontal
Genetic Engineering* / ethics
Genetic Predisposition to Disease / prevention & control*
Genome, Human*
Genomics
Germ Cells*
Humans
Risk Management
Targeted Gene Repair*

Abstract

Publication types

MeSH terms

Grants and funding