The effect of statins on perioperative inflammation in cardiac and thoracic surgery

Neel R Sodha; Frank W Sellke

doi:10.1016/j.jtcvs.2015.02.005

The effect of statins on perioperative inflammation in cardiac and thoracic surgery

J Thorac Cardiovasc Surg. 2015 Jun;149(6):1495-501. doi: 10.1016/j.jtcvs.2015.02.005. Epub 2015 Feb 11.

Authors

Neel R Sodha¹, Frank W Sellke²

Affiliations

¹ Division of Cardiothoracic Surgery, Alpert Medical School of Brown University, Providence, RI.
² Division of Cardiothoracic Surgery, Alpert Medical School of Brown University, Providence, RI. Electronic address: fsellke@lifespan.org.

PMID: 25791954
DOI: 10.1016/j.jtcvs.2015.02.005

Abstract

Statins are being used with increasing frequency for indications beyond lipid-lowering therapy. In the perioperative setting, the use of statins as anti-inflammatory agents has been an area of growing interest. Despite the early clinical adoption, the data are controversial. Herein we review the available clinical trials examining the effects of statin therapy on perioperative markers of inflammation in cardiac and thoracic surgery.

Publication types

Review

MeSH terms

Animals
Anti-Inflammatory Agents / therapeutic use*
Cardiac Surgical Procedures / adverse effects*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Inflammation / blood
Inflammation / etiology
Inflammation / prevention & control*
Inflammation Mediators / blood
Thoracic Surgical Procedures / adverse effects*
Treatment Outcome

Substances

Anti-Inflammatory Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inflammation Mediators