Fueling up skeletal muscle to reduce obesity: A TrkB story

Chem Biol. 2015 Mar 19;22(3):311-2. doi: 10.1016/j.chembiol.2015.03.004.

Abstract

Targeting TrkB signaling could represent a good therapeutic strategy to prevent obesity. In this issue of Chemistry & Biology, Chan et al. report the efficacy of 7,8-DHT, a TrkB agonist, in preventing obesity in female mice. The underlying molecular mechanisms behind this activity seem to involve increased energy expenditure in skeletal muscle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Female
  • Flavones / pharmacology*
  • Humans
  • Male
  • Membrane Glycoproteins / agonists*
  • Obesity / drug therapy*

Substances

  • Flavones
  • Membrane Glycoproteins