General CuBr2-catalyzed highly enantioselective approach for optically active allenols from terminal alkynols

Chem Commun (Camb). 2015 Apr 25;51(32):6956-9. doi: 10.1039/c5cc00697j. Epub 2015 Mar 23.

Abstract

Here, we show a CuBr2-catalyzed approach for a highly enantioselective synthesis (93-99% ee) of allenols from aldehydes and terminal alkynols with the absolute configuration being controlled by applying readily available (R)- or (S)-α,α-diphenylprolinol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Alkynes / chemistry*
  • Bromides / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Optical Phenomena*
  • Stereoisomerism

Substances

  • Alkenes
  • Alkynes
  • Bromides
  • cupric bromide
  • Copper