Myelodysplastic syndrome with clonal cytogenetic abnormalities followed by fatal erythroid leukemia after 14 years of exposure to hydroxyurea for sickle cell anemia

Am J Hematol. 2015 Jul;90(7):E131-2. doi: 10.1002/ajh.24010.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Anemia, Sickle Cell / complications*
  • Anemia, Sickle Cell / drug therapy
  • Anemia, Sickle Cell / genetics
  • Anemia, Sickle Cell / pathology
  • Antineoplastic Agents / therapeutic use
  • Antisickling Agents / therapeutic use*
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 17
  • Chromosomes, Human, Pair 5
  • Clone Cells
  • Erythroblasts / metabolism
  • Erythroblasts / pathology
  • Fatal Outcome
  • Granulocyte Precursor Cells / metabolism
  • Granulocyte Precursor Cells / pathology
  • Humans
  • Hydroxyurea / therapeutic use*
  • Karyotype
  • Leukemia, Erythroblastic, Acute / complications*
  • Leukemia, Erythroblastic, Acute / drug therapy
  • Leukemia, Erythroblastic, Acute / genetics
  • Leukemia, Erythroblastic, Acute / pathology
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / complications*
  • Myelodysplastic Syndromes / drug therapy
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / pathology

Substances

  • Antineoplastic Agents
  • Antisickling Agents
  • Hydroxyurea