Fatty acid metabolism meets organelle dynamics

Laurence Walch; Alenka Čopič; Catherine L Jackson

doi:10.1016/j.devcel.2015.03.008

Fatty acid metabolism meets organelle dynamics

Dev Cell. 2015 Mar 23;32(6):657-8. doi: 10.1016/j.devcel.2015.03.008.

Authors

Laurence Walch¹, Alenka Čopič¹, Catherine L Jackson²

Affiliations

¹ Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France.
² Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France. Electronic address: jackson@ijm.univ-paris-diderot.fr.

PMID: 25805129
DOI: 10.1016/j.devcel.2015.03.008

Abstract

Upon nutrient deprivation, cells metabolize fatty acids (FAs) in mitochondria to supply energy, but how FAs, stored as triacylglycerols in lipid droplets, reach mitochondria has been mysterious. Rambold et al. (2015) now show that FA mobilization depends on triacylglycerol lipolysis, whereas autophagy feeds the lipid droplet pool for continued fueling of mitochondria.

Publication types

Comment

MeSH terms

Animals
Autophagy / physiology*
Fatty Acids / metabolism*
Lipolysis / physiology*
Mitochondrial Dynamics / physiology*
Starvation / metabolism*

Substances

Fatty Acids