Nerve growth factor and inducible nitric oxide synthase expression in the mesencephalon and diencephalon, as well as visual- and auditory-related nervous tissues, in a macaque model of type 2 diabetes

Qihui Luo; Wentao Liu; Jingyao Chen; Mingshu Wang; Wen Zeng; Zhengli Chen; Anchun Cheng

doi:10.3969/j.issn.1673-5374.2012.04.011

Nerve growth factor and inducible nitric oxide synthase expression in the mesencephalon and diencephalon, as well as visual- and auditory-related nervous tissues, in a macaque model of type 2 diabetes

Neural Regen Res. 2012 Feb 5;7(4):302-7. doi: 10.3969/j.issn.1673-5374.2012.04.011.

Authors

Qihui Luo¹, Wentao Liu², Jingyao Chen², Mingshu Wang¹, Wen Zeng³, Zhengli Chen¹, Anchun Cheng¹

Affiliations

¹ College of Veterinary Medicine, Sichuan Agricultural University/Key Laboratory of Animal Disease and Human Health of Sichuan Province, Ya'an 625014, Sichuan Province, China ; Experimental Animal Engineering Center, Sichuan Agricultural University/Provenance Source De pot of Macaque for National Experiment, Ya'an 625014, Sichuan Province, China ; Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China.
² College of Veterinary Medicine, Sichuan Agricultural University/Key Laboratory of Animal Disease and Human Health of Sichuan Province, Ya'an 625014, Sichuan Province, China ; Experimental Animal Engineering Center, Sichuan Agricultural University/Provenance Source De pot of Macaque for National Experiment, Ya'an 625014, Sichuan Province, China.
³ Experimental Animal Engineering Center, Sichuan Agricultural University/Provenance Source De pot of Macaque for National Experiment, Ya'an 625014, Sichuan Province, China ; Sinopharm Center for Safety Evaluation and Research, Chengdu 610051, Sichuan Province, China.

PMID: 25806073
PMCID: PMC4353104
DOI: 10.3969/j.issn.1673-5374.2012.04.011

Abstract

The present study detected distribution and expression of nerve growth factor and inducible nitric oxide synthase in the mesencephalon and diencephalon, as well as visual- and auditory-related nervous tissues, in a macaque model of type 2 diabetes using immunohistochemistry. Results showed that nerve growth factor expression decreased, but inducible nitric oxide synthase expression increased, in the mesencephalon and diencephalon, as well as visual- and auditory- related nervous tissues. These results suggested that nerve growth factor and inducible nitric oxide synthase play an important role in regulating the development of diabetic visual- and auditory-related diseases.

Keywords: diencephalon; immunohistochemistry; inducible nitric oxide synthase; mesencephalon; nerve growth factor; neural regeneration; optic nerve; type 2 diabetes.