Sebaceous carcinoma in association with actinic keratosis: A report of two cases with an immunohistochemical study

J Dermatol. 2015 Jun;42(6):616-20. doi: 10.1111/1346-8138.12840. Epub 2015 Mar 21.

Abstract

We report two cases of sebaceous carcinoma associated with actinic keratosis (AK) with an immunohistochemical study, which suggests the possibility that sebaceous carcinoma really does develop within AK. Case 1 had sebaceous carcinoma arising within the atrophic type AK and case 2 had sebaceous carcinoma associated with bowenoid AK in the periphery and some parts of the overlying epidermis of the lesion.

Keywords: adipophilin; atrophic type actinic keratosis; bowenoid type actinic keratosis; cytokeratin 1; sebaceous carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Sebaceous / chemistry
  • Adenocarcinoma, Sebaceous / complications*
  • Adenocarcinoma, Sebaceous / pathology
  • Aged, 80 and over
  • Female
  • Humans
  • Keratosis, Actinic / complications*
  • Keratosis, Actinic / metabolism
  • Keratosis, Actinic / pathology
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / complications*
  • Skin Neoplasms / pathology