Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Cameron McDonald-Hyman; Laurence A Turka; Bruce R Blazar

doi:10.1126/scitranslmed.aaa6853

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Sci Transl Med. 2015 Mar 25;7(280):280rv2. doi: 10.1126/scitranslmed.aaa6853.

Authors

Cameron McDonald-Hyman¹, Laurence A Turka², Bruce R Blazar³

Affiliations

¹ Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.
² Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.Immune Tolerance Network, Massachusetts General Hospital, Boston, MA 02114, USA. Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.Immune Tolerance Network, Massachusetts General Hospital, Boston, MA 02114, USA. blaza001@umn.edu lturka@partners.org.
³ Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA. blaza001@umn.edu lturka@partners.org.

Abstract

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Clinical Trials as Topic
Hematopoietic Stem Cell Transplantation*
Humans
Immunotherapy*
Organ Transplantation*

Abstract

Publication types

MeSH terms

Grants and funding