The possible role of glutathione-S-transferase activity in diabetic nephropathy

Int J Immunopathol Pharmacol. 2015 Mar;28(1):129-33. doi: 10.1177/0394632015572564.

Abstract

The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication.

Keywords: biomarkers; diabetic nephropathy; glutathione-S-transferase; oxidative stress.

Publication types

  • Letter
  • Review

MeSH terms

  • Biomarkers / metabolism
  • Diabetes Complications / metabolism*
  • Diabetic Nephropathies / metabolism*
  • Glutathione Transferase / metabolism*
  • Humans
  • Kidney Failure, Chronic / metabolism
  • Renal Insufficiency, Chronic / metabolism

Substances

  • Biomarkers
  • Glutathione Transferase