Allele-specific PCR is a powerful tool for the detection of the MYD88 L265P mutation in diffuse large B cell lymphoma and decalcified bone marrow samples

Annette M Staiger; M Michaela Ott; Stefani Parmentier; Andreas Rosenwald; German Ott; Heike Horn; Ernst-Ulrich Griese

doi:10.1111/bjh.13369

Allele-specific PCR is a powerful tool for the detection of the MYD88 L265P mutation in diffuse large B cell lymphoma and decalcified bone marrow samples

Br J Haematol. 2015 Oct;171(1):145-8. doi: 10.1111/bjh.13369. Epub 2015 Mar 30.

Authors

Annette M Staiger^{1

2}, M Michaela Ott³, Stefani Parmentier⁴, Andreas Rosenwald⁵, German Ott⁶, Heike Horn^{1

2}, Ernst-Ulrich Griese^{1

2}

Affiliations

¹ Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
² University of Tuebingen, Stuttgart, Germany.
³ Department of Pathology, MVZ Klinikum Ludwigsburg, Ludwigsburg, Germany.
⁴ Department of Haematology and Oncology, Rems-Murr-Kliniken Winnenden, Germany.
⁵ Institute of Pathology, University of Würzburg, Würzburg, Germany and Comprehensive Cancer Centre Mainfranken (CCCM).
⁶ Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. german.ott@mail.rbk.de.

PMID: 25816840
DOI: 10.1111/bjh.13369

No abstract available

Keywords: MYD88 L265P; allele-specific polymerase chain reaction; diffuse large B-cell lymphomas; lymphoplasmacytic lymphoma; molecular diagnostics.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Amino Acid Substitution
Bone Marrow*
Cell Line, Tumor
Humans
Lymphoma, Large B-Cell, Diffuse / genetics*
Lymphoma, Large B-Cell, Diffuse / pathology
Mutation, Missense*
Myeloid Differentiation Factor 88 / genetics*
Neoplasm Proteins / genetics*
Polymerase Chain Reaction*

Substances

MYD88 protein, human
Myeloid Differentiation Factor 88
Neoplasm Proteins