Mediastinoscopic extended thymectomy for pediatric patients with myasthenia gravis

J Pediatr Surg. 2015 Apr;50(4):528-30. doi: 10.1016/j.jpedsurg.2014.08.012. Epub 2014 Oct 1.

Abstract

Background: Extended thymectomy is indicated for children with myasthenia gravis (MG) when drug-resistance or dependence is seen. We have employed a technique for mediastinoscopic extended thymectomy (MET) on children with MG.

Method: A total of 14 children underwent MET at Kanagawa Children's Medical Center between 2005 and 2013. A mediastinal operation field was made by a V-shaped hook infrasternally to extirpate the thymus with adipose tissue around the thymus.

Results: The operation time and the amount of blood loss were 182±44 minutes and 34±43 ml, respectively. Postoperative complications, in the form of transient paralysis of the right recurrent nerve, occurred in 2 patients. The median length of postoperative hospital stay was 4.5 days. After MET, 6 patients achieved complete remission and 7 patients achieved steroid dose reduction, but no improvement was seen in 1 patient.

Conclusions: This procedure offers the advantage of good surgical access for dissection around the bilateral phrenic nerves in extended total thymectomy, while achieving good cosmetic results.

Keywords: Children; Endoscopic surgery; Mediastinoscopy; Myasthenia gravis.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Mediastinoscopy / methods*
  • Microsurgery / methods*
  • Myasthenia Gravis / surgery*
  • Thymectomy / methods*
  • Treatment Outcome