The zDHHC family of S-acyltransferases

Biochem Soc Trans. 2015 Apr;43(2):217-21. doi: 10.1042/BST20140270.

Abstract

The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acylation / genetics*
  • Acyltransferases / genetics*
  • Acyltransferases / metabolism
  • Humans
  • Multigene Family / genetics
  • Substrate Specificity

Substances

  • Acyltransferases
  • ZDHHC1 protein, human