Fatal Acute Myeloid Leukemia With 11q23 MLL Gene Rearrangement Following Mitoxantrone Treatment in a Case of Childhood-onset Multiple Sclerosis

J Pediatr Hematol Oncol. 2015 Jul;37(5):413-4. doi: 10.1097/MPH.0000000000000336.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adolescent
  • Chromosomes, Human, Pair 11 / genetics
  • Fatal Outcome
  • Female
  • Gene Rearrangement
  • Histone-Lysine N-Methyltransferase / genetics*
  • Humans
  • Leukemia, Myeloid, Acute / chemically induced*
  • Leukemia, Myeloid, Acute / genetics
  • Mitoxantrone / adverse effects*
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Topoisomerase II Inhibitors / adverse effects*

Substances

  • KMT2A protein, human
  • Topoisomerase II Inhibitors
  • Myeloid-Lymphoid Leukemia Protein
  • Mitoxantrone
  • Histone-Lysine N-Methyltransferase