Inner and outer retinal thickness mapping of nonproliferative diabetic retinopathy by spectral-domain optical coherence tomography

Ophthalmic Surg Lasers Imaging Retina. 2015 Mar;46(3):316-20. doi: 10.3928/23258160-20150323-03.

Abstract

Background and objective: To report inner retinal thickness (IRT), outer retinal thickness (ORT), and total retinal thickness (TRT) mapping of nonproliferative diabetic retinopathy (DR).

Patients and methods: Spectral-domain optical coherence tomography (SD-OCT) images were obtained in 31 study participants with nonproliferative DR. Semi-automated software generated IRT, ORT, and TRT maps. IRT, ORT, and TRT in each macular subfield were compared between groups with and without increased central subfield thickness.

Results: There were statistically significant differences in IRT, ORT, and TRT between groups (P < .007). In participants with nonproliferative DR with increased central subfield thickness, TRT was significantly increased in parafoveal and perifoveal inferior subfields (P < .001). In these subfields, both IRT and ORT were significantly increased (P < .007) compared to those in participants without increased central subfield thickness.

Conclusion: Mapping of inner and outer retinal thickness shows promise for monitoring depth-specific thickness alterations by macular subfields due to DR.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Diabetic Retinopathy / diagnosis*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Macular Edema / diagnosis*
  • Male
  • Middle Aged
  • Organ Size
  • Retina / pathology*
  • Tomography, Optical Coherence*