Pushing the limits of signal resolution to make coupling measurement easier

Chem Commun (Camb). 2015 May 7;51(37):7939-42. doi: 10.1039/c5cc01305d.

Abstract

Probing scalar couplings are essential for structural elucidation in molecular (bio)chemistry. While the measurement of JHH couplings is facilitated by SERF experiments, overcrowded signals represent a significant limitation. Here, a new band selective pure shift SERF allows access to δ(1)H and JHH with an ultrahigh spectral resolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Limit of Detection*
  • Magnetic Resonance Spectroscopy / methods*
  • Peptides / chemistry*

Substances

  • Peptides