A small part of myosin IIB takes on a big role in cell polarity

J Cell Biol. 2015 Apr 13;209(1):11-2. doi: 10.1083/jcb.201503079.

Abstract

A migrating cell must establish front-to-back polarity in order to move. In this issue, Juanes-Garcia et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201407059) report that a short serine-rich motif in nonmuscle myosin IIB is required to establish the cell's rear. This motif represents a new paradigm for what determines directional cell migration.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Polarity*
  • Humans
  • Myosin Heavy Chains / physiology*
  • Nonmuscle Myosin Type IIB / physiology*

Substances

  • Nonmuscle Myosin Type IIB
  • Myosin Heavy Chains