Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation

Int Immunopharmacol. 2015 Oct;28(2):854-8. doi: 10.1016/j.intimp.2015.03.041. Epub 2015 Apr 11.

Abstract

The miR-17-92 cluster is a prototypical example of a polycistronic miRNA gene. Recently, miR-17-92 has emerged as a pleiotropic regulator in immune system. Its loss or deregulation leads to defects in lymphocyte development and response, and lymphoma development. Although the six individual miRNAs of the cluster are expressed together from the same primary transcript, their relative abundance, functional contributions and interactions vary in different cellular contexts.

Keywords: B cells; Lymphoma; T cells; miR-17–92; miRNA clusters; microRNAs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Transformation, Neoplastic
  • Hematologic Neoplasms / immunology
  • Humans
  • Immune Tolerance
  • Lymphocytes* / cytology
  • Lymphocytes* / immunology
  • Lymphocytes* / pathology
  • MicroRNAs / immunology*
  • RNA, Long Noncoding

Substances

  • MIR17HG, human
  • MIRN17-92 microRNA, mouse
  • MicroRNAs
  • RNA, Long Noncoding