Time-Varying Network Measures in Resting and Task States Using Graph Theoretical Analysis

Brain Topogr. 2015 Jul;28(4):529-40. doi: 10.1007/s10548-015-0432-8. Epub 2015 Apr 16.

Abstract

Recent studies have shown the importance of graph theory in analyzing characteristic features of functional networks of the human brain. However, many of these explorations have focused on static patterns of a representative graph that describe the relatively long-term brain activity. Therefore, this study established and characterized functional networks based on the synchronization likelihood and graph theory. Quasidynamic graphs were constructed simply by dividing a long-term static graph into a sequence of subgraphs that each had a timescale of 1 s. Irregular changes were then used to investigate differences in human brain networks between resting and math-operation states using magnetoencephalography, which may provide insights into the functional substrates underlying logical reasoning. We found that graph properties could differ from brain frequency rhythms, with a higher frequency indicating a lower small-worldness, while changes in human brain state altered the functional networks into more-centralized and segregated distributions according to the task requirements. Time-varying connectivity maps could provide detailed information about the structure distribution. The frontal theta activity represents the essential foundation and may subsequently interact with high-frequency activity in cognitive processing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / physiology*
  • Brain Mapping / methods*
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetoencephalography / methods*
  • Male
  • Nerve Net / physiology*
  • Time Factors