Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia

Pediatr Blood Cancer. 2015 Sep;62(9):1674-6. doi: 10.1002/pbc.25554. Epub 2015 Apr 20.

Abstract

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19(+) B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia.

Keywords: X-linked agammaglobulinemia; acute myeloid leukemia; stem cell transplantation.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinemia / complications
  • Agammaglobulinemia / therapy*
  • Allografts
  • Antibodies, Bacterial / biosynthesis
  • Antigens, CD19 / analysis
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • B-Lymphocyte Subsets / chemistry
  • Child, Preschool
  • Combined Modality Therapy
  • Genetic Diseases, X-Linked / complications
  • Genetic Diseases, X-Linked / therapy*
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / therapy*
  • Lymphocyte Count
  • Male
  • Peripheral Blood Stem Cell Transplantation*
  • Pneumococcal Vaccines
  • Recurrence
  • Remission Induction
  • Streptococcus pneumoniae / immunology
  • Transplantation Conditioning

Substances

  • Antibodies, Bacterial
  • Antigens, CD19
  • Immunoglobulins, Intravenous
  • Pneumococcal Vaccines

Supplementary concepts

  • Bruton type agammaglobulinemia