Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis

Andrew M Rosen; Timothy Spellman; Joshua A Gordon

doi:10.1016/j.biopsych.2015.03.021

Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis

Biol Psychiatry. 2015 Jun 15;77(12):1041-9. doi: 10.1016/j.biopsych.2015.03.021. Epub 2015 Mar 27.

Authors

Andrew M Rosen¹, Timothy Spellman², Joshua A Gordon³

Affiliations

¹ Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.
² Department of Physiology, College of Physicians and Surgeons, Columbia University, New York, New York.
³ Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York; Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, New York.. Electronic address: jg343@columbia.edu.

Abstract

Schizophrenia is caused by a diverse array of risk factors and results in a similarly diverse set of symptoms. Electrophysiological endophenotypes lie between risks and symptoms and have the potential to link the two. Electrophysiological studies in rodent models, described here, demonstrate that widely differing risk factors result in a similar set of core electrophysiological endophenotypes, suggesting the possibility of a shared neurobiological substrate.

Keywords: EEG; Excitation/inhibition balance; Local field potentials; Oscillations; Schizophrenia; Synaptic plasticity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / physiopathology
Disease Models, Animal*
Endophenotypes*
Genetic Predisposition to Disease
Humans
Neural Inhibition
Psychotic Disorders / genetics*
Psychotic Disorders / physiopathology*
Rats
Risk Factors
Schizophrenia / genetics*
Schizophrenia / physiopathology*
Schizophrenic Psychology*

Abstract

Publication types

MeSH terms

Grants and funding