Triterpenoids as neutrophil elastase inhibitors

Nat Prod Commun. 2015 Jan;10(1):167-70.

Abstract

Neutrophile elastase has the capacity to degrade elastin, a protein found in the connective tissue of the lungs. Unchecked elastase leads to pulmonary pathologies. Therefore, the development of elastase inhibitors is currently actively pursued in the therapeutic field. Several triterpenoids have been reported as inhibitors against elastase or its release. Such compounds could be valuable for the design of new drugs. This review is aimed at giving a comprehensive insight into the recent work performed in the field of triterpenoid-induced elastase inhibition.

Publication types

  • Review

MeSH terms

  • Proteinase Inhibitory Proteins, Secretory / chemistry*
  • Triterpenes / chemistry*

Substances

  • Proteinase Inhibitory Proteins, Secretory
  • Triterpenes