Hepatocellular carcinoma in children

Deirdre Kelly; Khalid Sharif; Rachel M Brown; Bruce Morland

doi:10.1016/j.cld.2015.01.010

Hepatocellular carcinoma in children

Clin Liver Dis. 2015 May;19(2):433-47. doi: 10.1016/j.cld.2015.01.010. Epub 2015 Feb 28.

Authors

Deirdre Kelly¹, Khalid Sharif², Rachel M Brown³, Bruce Morland⁴

Affiliations

¹ The Liver Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. Electronic address: deirdre.kelly@bch.nhs.uk.
² The Liver Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.
³ Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK.
⁴ Oncology Department, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.

PMID: 25921672
DOI: 10.1016/j.cld.2015.01.010

Abstract

Liver tumors are relatively rare in childhood, but may be associated with a range of diagnostic, genetic, therapeutic, and surgical challenges sufficient to tax even the most experienced clinician. This article outlines the epidemiology, etiology, pathologic condition, initial workup, and management of hepatocellular carcinoma in children and adolescents.

Keywords: Carcinoma; Epidemiology; Hepatocellular; Histopathology; Outcome; Pediatrics; Transplant.

Publication types

Review

MeSH terms

Adolescent
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / therapeutic use*
Carcinoma, Hepatocellular / diagnosis*
Carcinoma, Hepatocellular / epidemiology
Carcinoma, Hepatocellular / etiology
Carcinoma, Hepatocellular / therapy*
Chemoembolization, Therapeutic
Child
Diagnosis, Differential
Hepatectomy
Hepatoblastoma / diagnosis*
Humans
Liver Neoplasms / diagnosis*
Liver Neoplasms / epidemiology
Liver Neoplasms / etiology
Liver Neoplasms / therapy*
Liver Transplantation
Neoplasm Staging
Treatment Outcome

Substances

Antineoplastic Agents

Supplementary concepts

Fibrolamellar hepatocellular carcinoma