A combination of alfaxalone and medetomidine followed by an alfaxalone continuous rate infusion in cynomolgus monkeys (Macaca fascicularis) undergoing pharmacoMRS

Vet Anaesth Analg. 2015 Sep;42(5):552-4. doi: 10.1111/vaa.12267. Epub 2015 May 5.

Authors

Daniela Casoni¹, Eva M Amen², Mathieu Brecheisen², Basil Kuennecke³, Thomas Müggler³, Alessandra Bergadano²

Affiliations

¹ Anaesthesia and Pain Therapy Division, Department of Clinical Veterinary Sciences, School of Veterinary Medicine, University of Berne, Berne, Switzerland. daniela.casoni@vetsuisse.unibe.ch.
² Department of Comparative Medicine, F. Hoffmann-La Roche AG, Basel, Switzerland.
³ pRED, Pharma Research & Early Development, DTA Neuroscience, F. Hoffmann-La Roche AG, Basel, Switzerland.

PMID: 25943584
DOI: 10.1111/vaa.12267

No abstract available

Publication types

Letter

MeSH terms

Anesthesia / veterinary
Anesthetics / administration & dosage*
Anesthetics, Intravenous / administration & dosage*
Animals
Dose-Response Relationship, Drug
Heart Rate / drug effects
Infusion Pumps / veterinary
Infusions, Intravenous / veterinary
Injections, Intramuscular / veterinary
Macaca fascicularis / physiology*
Magnetic Resonance Spectroscopy
Male
Medetomidine / administration & dosage*
Pregnanediones / administration & dosage*
Respiration / drug effects
Treatment Outcome

Substances

Anesthetics
Anesthetics, Intravenous
Pregnanediones
alphaxalone
Medetomidine