A comparison of the Xpert(®) MTB/RIF and GenoType(®) MTBDRplus assays in Georgia

Int J Tuberc Lung Dis. 2015 Jun;19(6):676-8. doi: 10.5588/ijtld.14.0867.

Abstract

Few studies have directly compared the performance of rapid molecular diagnostic tests for tuberculosis (TB). We found that the commercially available molecular diagnostic tests Xpert(®) MTB/RIF and GenoType(®) MTBDRplus both provided timely and accurate results compared to conventional phenotypic tests in detecting TB and rifampicin resistance.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Genotype
  • Georgia (Republic)
  • Humans
  • Microbial Sensitivity Tests*
  • Molecular Diagnostic Techniques*
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification
  • Phenotype
  • Predictive Value of Tests
  • Sputum / microbiology
  • Time Factors
  • Tuberculosis, Multidrug-Resistant / diagnosis*
  • Tuberculosis, Multidrug-Resistant / drug therapy
  • Tuberculosis, Multidrug-Resistant / microbiology
  • Tuberculosis, Pulmonary / diagnosis*
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / microbiology

Substances

  • Antitubercular Agents
  • DNA, Bacterial